The interview focused on JavaScript and TypeScript fundamentals, including array methods, promises, asynchronous programming, equality operators, types and interfaces, loops, and conditional statements. The React Native discussion covered the new architecture, Fabric, TurboModules, the React Native bridge, Redux Toolkit, project upgrades, FlatList, React Hooks, in-app purchase validation, testing and beta releases, deep linking, Expo, component lifecycle, foreground and background execution, and local storage with SQLite and AsyncStorage.